Metal-mediated base pairs in parallel-stranded DNA
نویسندگان
چکیده
منابع مشابه
Metal-mediated base pairs in parallel-stranded DNA
In nucleic acid chemistry, metal-mediated base pairs represent a versatile method for the site-specific introduction of metal-based functionality. In metal-mediated base pairs, the hydrogen bonds between complementary nucleobases are replaced by coordinate bonds to one or two transition metal ions located in the helical core. In recent years, the concept of metal-mediated base pairing has found...
متن کاملChimeric GNA/DNA metal-mediated base pairs.
DNA double helices comprising chimeric GNA/DNA metal-mediated base pairs have been synthesized and characterized (GNA = glycol nucleic acid). The possibility to combine different nucleic acid backbones within one metal-mediated base pair expands the applicability of metal-functionalized nucleic acids.
متن کاملParallel-stranded duplex DNA containing blocks of trans purine-purine and purine-pyrimidine base pairs.
A 30 base pair parallel-stranded (ps) duplex ps-L1.L2 composed of two adjoined purine-purine and purine-pyrimidine sequence blocks has been characterized thermodynamically and spectroscopically. The 5'-terminal 15 residues in both strands ('left-half') consisted of the alternating d(GA)7G sequence that forms a ps homoduplex secondary structure stabilized by d(G.G) and d(A.A) base pairs. The 3'-...
متن کاملSolution structure of a DNA double helix with consecutive metal-mediated base pairs.
Metal-mediated base pairs represent a powerful tool for the site-specific functionalization of nucleic acids with metal ions. The development of applications of the metal-modified nucleic acids will depend on the availability of structural information on these double helices. We present here the NMR solution structure of a self-complementary DNA oligonucleotide with three consecutive imidazole ...
متن کاملA QM/MM refinement of an experimental DNA structure with metal-mediated base pairs.
A series of hybrid quantum mechanical/molecular mechanical (QM/MM) calculations was performed on models of a DNA duplex with artificial silver(I)-mediated imidazole base pairs. The optimized structures were compared to the original experimental NMR structure (Nat. Chem. 2 (2010) 229-234). The metal⋯metal distances are significantly shorter (~0.5Å) in the QM/MM model than in the original NMR str...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2017
ISSN: 1860-5397
DOI: 10.3762/bjoc.13.265